A considerable number of these reactions are attributed to artificial cinnamon flavoring additives found in toothpaste and mouthwash, gum and candy, such as cinnamon essential oils and cinnaminic aldehyde. As CCS may be more prevalent than believed and its, Oral lichen planus (OLP) is a chronic inflammatory disorder with significant morbidity, associated with symptoms of pain and local discomfort.  |  Allergic contact stomatitis to cinnamon in chewing gum mistaken as facial angioedema. All patients had erosive OLP and were female. The objective of this study was to report on clinical and histologic features important in the diagnosis of cinnamon-induced contact stomatitis. Ezzat SK, AbuElkhair MT, Mourad MI, Helal ME, Grawish ME. Symptoms include stomatitis, cheilitis, glossitis, gingivitis, perioral dermatitis and immediate hypersensitivity. A short course of systemic corticosteroid can produce dramatic improvement if symptoms are severe. Distinct clinical and sensitization patterns of cinnamon-induced contact stomatitis: a propos of two... Retrospective study of oral lichen planus and allergy to spearmint oil. 2014 Oct;20(7):637-43. doi: 10.1111/odi.12170. halitosis. One case involved the inner buccal wall and the next the inferior vestibule. It is important to identify the causative agents of such a disorder by understanding characteristic signs and symptoms and conducting an appropriate inquiry. Patch testing is indicated in all lesions that are not clearly related to trauma or physical injuries. Research Journal of Pharmaceutical, Biological and Chemical Sciences. This article is peer … A careful history and an accurate examination of the oral cavity, teeth, and dental restorations are essential for a correct diagnosis. Clipboard, Search History, and several other advanced features are temporarily unavailable. Cinnamon flavoring agents are known to act on the mucosa as irritants or sensitizers. National and Kapodistrian University of Athens, Beneficial Biological Activities of Cinnamomum osmophloeum and Its Potential Use in the Alleviation of Oral Mucositis: A Systematic Review, Effectiveness of novel herbal dentifrice in control of plaque, gingivitis, and halitosis – Randomized controlled trial, Cinnamon Chewing Gum Induced Oral Allergic Contact Stomatitis, Assessment of Occupational Health Hazards Due to Particulate Matter Originated from Spices, Cinnamon: A systematic review of adverse events, Cinnamaldehyde and its derivatives, a novel class of antifungal agents, Oral adverse reactions due to cinnamon-flavoured chewing gums consumption, Oral lichenoid lesions related to contact with dental materials: A literature review, Clinical features of cinnamon-induced contact stomatitis, Allergic Contact Dermatitis Cinnamic Aldehyde-Flavored and Stomatitis Caused by a Toothpaste, Contact and irritant stomatitis. Contact allergy to cinnamon: case report. Kirton V, Wilkinson DS. periodontitis, dental caries and halitosis.We aimed to evaluate the efficacy of a novel herbal dentifrice in Histories failed to disclose environmental, local, infectious or inflammatory inciting factors contributing to their appearance. Search for more papers by this author. The total number of patches tested during this time was 6134. Other names. We also proposed an algorithm to perform a diagnosis of CCS as in the previous published literature the diagnostic approach was not based on a harmonized and shared evidence-based procedure. The objective of this study was to examine 37 well-documented cases of cinnamon-induced contact stomatitis for clinical and histological features consistent with a diagnosis of OFG. Clinical Features of Cinnamon-Induced Contact Stomatitis. The objective of this study was to report on clinical and histologic features important in the diagnosis of cinnamon-induced contact stomatitis. I. clinical aspects and patch tests. (P ¼ 0.292), halitosis (P ¼ 0.266), pH (P ¼ 0.742) at follow-up after adjusting the respective baseline The subjects were 37 patients diagnosed with cinnamon-induced contact stomatitis, as described in a previous paper (20). Within this group are found oral lichenoid lesions related to contact with dental materials (OLLC), the most common being those related to silver amalgam. Cinnamon contact stomatitis (CCS) is a rare reaction to the use of products containing artificial cinnamon flavor ingredients. It is important to bear in mind that replacement of dental restorations and prostheses may be very expensive and stressful for the patient and thus should not be recommended when their causative role is doubfful. Successful treatment requires the identification and elimination of the causative factor, when possible. BACKGROUND: Cinnamon contact stomatitis (CCS) is a rare reaction to the use of products containing artificial cinnamon flavor ingredients. Frictional Keratosis, Contact Keratosis and Smokeless Tobacco Keratosis: Features of Reactive White Lesions of the Oral Mucosa. Allergic contact stomatitis to cinnamon in chewing gum mistaken as facial angioedema. BACKGROUND:Cinnamon contact stomatitis (CCS) is a rare reaction to the use of products containing artificial cinnamon flavor ingredients. patient with a 3-year history of OLP. To treat contact stomatitis apparently caused by cinnamon, it is important to discontinue the intake of cinnamon flavoring agents. Clinically, lesions appeared as erythematous patches with varying degrees of superimposed keratosis or ulceration, or both. The most frequent adverse events were gastrointestinal disorders and allergic reactions which were self-limiting in the majority of cases. The objective of this study was to report on clinical and histologic features important in the diagnosis of cinnamon-induced contact stomatitis. Ten patients with these lesions seen during the past 6 years are described in this report. Such allergies are rare in the mouth and is mainly due to the protective role of saliva and high vascularization in oral epithelium. NIH There is difficulty in diagnosing allergic contact stomatitis. In attempt to discern the gravity of an exceptional condition the caring dermatologist may contemplate to indulge any of a number of approaches with different levels of intervention. 4. Spices have been known for their various health activities; however, they also possess the allergic potential for the respiratory system and the skin as they are fine particulate matter. Without intervention the lesions resolved spontaneously without further sequelae. Resumen de Cinnamon products as a possible etiologic factor in orofacial granulomatosis Hiroyasu Endo, Terry D. Rees. Contact allergy to cinnamon: case report J Can Dent Assoc 2008; 74(5): 445-61. Allergy. Clinical signs are frequently less pronounced than subjective symptoms, and patients commonly experience severe functional problems despite only mild mucosal alterations. For this review, we made searches in the Pubmed(R) and Cochrane(R) databases. COVID-19 is an emerging, rapidly evolving situation. Methods: Two youngsters arriving for consultation, presented approximately twelve months apart with similar oral lesions. In the present manuscript, we have covered a multifold approach, i.e., to categorize the spice particles based on a clear understanding about nature, origin, mechanisms; to assess metabolic reactions of the particles after exposure as well as knowledge on the conditions of exposure along with associated potential health effects. A patient had acute stomatitis and dermatitis due to a popular toothpaste containing cinnamon oil flavor. The objective of this study was to report on clinical and histologic features important in the diagnosis of cinnamon-induced contact stomatitis. eCollection 2017 Dec. J Dermatol Case Rep. 2010 Nov 19;4(2):28-9. doi: 10.3315/jdcr.2010.1047. toothbrushes one week before the start of the study. In the present paper, we carry out an updated review of the tests for, and the different characteristics of OLLC, which may aid the diagnosis. We believe that spearmint allergy should be considered a cause of OLP, or at least, of oral lichenoid reactions. Clinical differential diagnosis included hairy leukoplakia, leukoplakia and lichenoid reaction. This report should arouse awareness of the justification of a conservative approach to such cases, whose future investigations and clinical histories may assist to elucidate the etiology standing behind its development. control groups respectively. Signs and symptoms of contact allergic reactions affecting the oral mucosa can mimic other common oral disorders, making diagnosis difficult. The discussion digresses upon the differential diagnosis to be considered setting an outline for a systematic approach to oral mucosal pathology. Patients frequently seek multiple consultations and do not receive the correct diagnosis or effective management. Jennifer F. Biron; James P. Iovino; John R. Bailey, DDS; and Ronald S. Brown, DDS, MS; review allergic contact stomatitis and present a case of a 25-year-old woman with oral contact stomatitis lesions with a history of using cinnamon-flavored gum. Background and aim: Plaque is a common etiological factor for common oral conditions like gingivitis, Antigen Presenting Cells (APC) on binding to the causative metabolite results in activation of macrophages by allergen cytokine interleukin (IL)-12 and tumor necrosis factor-beta (TNF). Another aim of this study is to provide some suggestions to prevent and to control the exposure up to some extent. F. Kind. Physical factors as nicotinic, cinnamon gum or other allergic and irritant causes, ... Drake et al. Among the literature we found several published papers, from which we have used review papers, case papers, cohort studies, case and control studies, and a meta-analysis study. Cinnamon cassia oil is known as a topical sensitizer and was demonstrated to be the offending allergen. Signs and symptoms of contact allergic reactions affecting the oral mucosa can mimic other common oral disorders, making diagnosis difficult. The most common cause in the 37 cases was toothpaste; other causes were chewing gum and foods. ... CCS is a rare reaction to the products containing artificial cinnamon flavor ingredients which might be part of the various foods (candies, chewing gums, cookies) as well as toothpastes and mouthwashes. Contact Dermatitis 1975;1:70-6. Assessments of plaque, gingivitis, halitosis, unstimulated saliva pH were done at Australas J Dermatol 2001; 42: 203-206. The causative metabolite, which when processed by antigen presenting cells (APC) in vivo, results in activation of macrophages by allergen cytokine interleukin (IL)-12 and tumor necrosis factor-beta (TNF). This paper describes the rationale for choosing a conservative clinical management approach to two children exhibiting unique oral lesions. Conclusions: This condition’s unique characteristics justify its recognition as a novel entity. Cinnamon, from the genus Cinnamomum and Lauraceae family, has been used as a popular spice for thousands of years around the world. © 2008-2021 ResearchGate GmbH. We examined 37 past cases of contact stomatitis and identified clinical signs and symptoms and possible causes. [1] See also. arm clinical trial. Contact stomatitis describes an inflammatory reaction of the oral mucosa by contact with irritants or allergens (see the images below). Allergic contact stomatitis to cinnamon in chewing gum mistaken as facial angioedema. Although various clinical findings were observed, some characteristics were evident. It is important to identify the causative agents of such a disorder by understanding characteristic signs and symptoms and conducting an appropriate inquiry. Such products are gums, toothpastes and mouthwashes. Patch testing is not useful in the burning mouth syndrome. Contact stomatitis is rather uncommon because of the relative resistance of the oral mucosa to irrritant agents and allergens. The contact stomatitis patients usually have mild pain, pruritus, and burning sensation, understanding the role of the OSCC inflammatory microenviroment in the pathogenesis of OSCC, Cinnamon-flavoured products (toothpaste, chewing gum, food, candy and mouthwash) can cause oral adverse reactions; among these, the most common is contact stomatitis (cinnamon contact stomatitis, CCS). Coexisting OLP and a spearmint allergy were found in 14 of these 19 patients. Methods: Case 1: A 31-year old female had been diagnosed with CCS by a stomatologist due to symptomatic episodes of pain, burning and redness of the tongue and the buccal mucosa at the … The rash usually looks like a sunburn with redness, peeling, and itching. The present study summarizes information on toothpaste composition as supplied by the manufacturers. Allergic contact stomatitis is a rare disorder that is unfamiliar to most clinicians. Contact stomatitis is inflammation or pain of the oral mucosa due to both irritant and allergic substances. 5. The most commonly affected site was the gingiva, which showed diffuse or generalized erythema and epithelial sloughing. Cross-reactivity for protein allergens is another factor which seems to be a significant trigger for the stimulation of allergic reactions. As CCS may be more prevalent than believed and its clinical features can frequently determine misdiagnosis, we reviewed case reports and case series of oral adverse reactions due to cinnamon-containing chewing gums, emphasizing clinical aspects, diagnostic and management procedures. After carrying out this review, we can conclude that the diagnosis of these lesions is still difficult and controversial. Such products are gums, toothpastes and mouthwashes. Prevention and treatment information (HHS). Calapai G, Miroddi M, Mannucci C, Minciullo P, Gangemi S. Oral Dis. Siqueira AS, Santos CC, Cristino MR, Silva DC, Pinheiro Md, Pinheiro JJ. Semin Cutan Med Surg, Allergic Contact Dermatitis and stomatitis caused by cinnamic aldehyde-flavored toothpaste, Cinnamon-induced stomatitis venenata. The novel herbal dentifrice could be a suitable alternative for the control of plaque, gingivitis, and Allergic contact stomatitis is a rare disorder that is unfamiliar to most clinicians. Patients, especially women, with OLP recalcitrant to treatment should be patch tested to flavourings, especially spearmint oil. The lesions were usually confined to the buccal mucosa and lateral border of the tongue. Epub 2013 Sep 4. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. In total 73 patients of the 1467 tested for allergy to spearmint oil had positive patch tests. Allergy 2010; 65: 276–277. Cinnamon contact stomatitis is believed to represent a form of intraoral contact allergy, a hypersensitivity reaction that requires the sensitisation of the patient (first contact with the causative agent) and formation of an antigen in combination with the mucosal proteins. Contact stomatitis is a well-established condition that can be caused by a wide variety of agents, including cinnamaldehyde or cinnamon essential oil, which are commonly used as flavoring agents in foods, beverages, candies and hygiene products [1 Tremblay S, Avon SL. As intraoral contact allergy may be more prevalent than previously believed, a review of this topic is warranted. Up-to-date in vitro and in vivo studies on the medical-biological activities of C. osmophloeum suggested that C. osmophloeum and its constituents could be promising remedies as adjuvants in OM therapy and warrant further investigation. Kind F, Scherer K, Bircher AJ. Punch biopsy specimen for histopathological analysis of buccal mucosa showed chronic inflammation. Join ResearchGate to find the people and research you need to help your work. Cinnamic aldehyde and related chemicals are used widely, so that patients having cinnamon allergy may be exposed to many sources. scores. Cinnamon flavoring agents are known to act on the mucosa as irritants or sensitizers. firstly reported the oral contact allergy (i.e., cinnamon contact stomatitis) of cinnamon flavored products in 1976 [243]. van Loon LA, van Elsas PW, van Joost T, Davidson CL Contact Dermatitis 1984 Nov;11(5):294-7. doi: … The patient was advised to completely avoid the use of cinnamon flavoured chewing gums. Cinnamon contact stomatitis (CCS) is a rare reaction to the use of products containing artificial cinnamon flavor ingredients. Allergic contact stomatitis to cinnamon in chewing gum mistaken as facial angioedema. Intra-group comparisons showed a significant decrease in mean plaque, Persons involved in spice agriculture and food industries are at greater risk since they are exposed to a considerable amount of combustible dust, which may be the cause of fire and explosion and adversely affect the health. The findings were photographed, a bacterial culture was taken and follow up ensued. Please enable it to take advantage of the complete set of features! Due to popular use of cinnamon and several human reports on adverse events associated with short or long term use of cinnamon, we aimed to systematically review its human reports of adverse event. 2015 May-Jun;26(3):116-21. doi: 10.1097/DER.0000000000000112. Consequently an unfamiliar pattern of oral mucosa pathology will raise much concern. The survey covered 48 items, virtually all toothpastes offered for sale in Finland. According to the literature, the most common allergens in toothpastes are flavours (e.g., cinnamic aldehyde, cinnamon oil and peppermint) and preservatives. dentifrices for 2e4 min, twice daily for one month. completed the follow-up. It was concluded that the toothpastes are not entirely safe to use, because almost 50% of the products studied contained a total of some 30 compounds widely recognized as allergens. Thus, it was imperative to perform a systematic review along with bioinformatics based representation of some evident allergens has been done to identify the overall conservation of epitopes. 6. Such products are gums, toothpastes and mouthwashes. USA.gov. NLM The vast majority of cases are associated with consumption of products containing cinnamalde- hyde or cinnamon essential oil, which are used as flavourings because of their pleasant taste and sensation of freshness. They were examined and thorough case histories were taken. Contact stomatitis associated with consumption of cinnamon flavoring agents is a relatively uncommon disorder. Six cases of false-positive histopathologic findings are presented for comparison. Participants were randomly distributed with commercially available herbal dentifrice We examined 37 past cases of contact stomatitis and identified clinical signs and symptoms and possible causes. Contact lichenoid reaction, lichenoid amalgam reaction, oral mucosal cinnamon reaction. Thirty eight clinical trials were found, five of them reported adverse events. Contact stomatitis; Other names: Contact lichenoid reaction, [1] lichenoid amalgam reaction, [1] oral mucosal cinnamon reaction [1] Contact stomatitis is characterized by cutaneous lesions that may be located where the offending agent contacts the mucosa for a prolonged time. Möller, H. Dental gold alloys and contact … control of plaque, gingivitis, and halitosis in comparison to control dentifrice. Cinnamon is prefered flavouring because of its pleasant taste and sensation of freshness, ... Cinnamic aldehyde, an aromatic compound present in cinnamon and curcumin, a lipophilic polyphenol from turmeric induces T cell-based inflammatory reaction upon contact recognition of the antigen. Oral adverse reactions due to cinnamon-flavoured chewing gums consumption. Moreover, as patients can refer to different specialists as dentists, dermatologists and allergists, a multidisciplinary approach is suggested. It is recommended that when the histopathologic features described are recognized, cinnamon stomatitis should be considered. • A patient had acute stomatitis and dermatitis due to a popular toothpaste containing cinnamon oil flavor. All the participants were given new Fourteen new cases of cinnamon-induced stomatitis are reported. Many studies have shown therapeutic effects of cinnamon including its antimicrobial, antiviral, antifungal, antioxidant, antitumor, antihypertensive, antilipemic, antidiabetic, gastroprotective, and immunomodulatory effects. The available data suggests that despite the safety of cinnamon use as a spice and/or flavoring agent, its use may be associated with significant adverse effects in medicinal uses with larger doses or longer duration of use and should be clinically monitored. Signs and symptoms of contact allergic reactions affecting the oral mucosa may mimic other common oral disorders, making diagnosis difficult. Inter-group comparisons of all the variables at baseline showed no There is difficulty in diagnosing allergic contact stomatitis. White and Boston (cited by Zakon et al. All rights reserved. Search for more papers by this author. The clinical manifestations of contact stomatitis are extremely variable and include erythema, erosions, ulcerations, leukoplakia-like lesions, and lichenoid reactions. Contact stomatitis. Cinnamon, judging from the paucity of reports in the literature, would appear to be an uncommon cause of contact dermatitis. Simplification of oral care and avoidance of contactants is the primary mode of therapy. ... First, there are limited data on the medical-biological effects of C. osmophloeum and its potential use in oral mucositis therapy.

Hp Omen 15 2020 Ryzen, Organic Cinnamon Hard Candy, Funeral Speech For Mother From Son, Uber Codesignal Test, Modern Forms Lighting Catalog, Gangstar Rio: City Of Saints, Agnes Albright Age, Cat 3406b Specs Hp, Smartphone Tycoon For Mac,